CHARACTERIZATION OF REGULATORY AND TRANSPORTER GENES IN THE BIOSYNTHESIS OF ANTI-TUBERCULOSIS ILAMYCINS AND PRODUCTION IN A HETEROLOGOUS HOST

Characterization of Regulatory and Transporter Genes in the Biosynthesis of Anti-Tuberculosis Ilamycins and Production in a Heterologous Host

Ilamycins are cyclopeptides with novel structures that have been isolated from different Actinomycetes.They showed strong anti-tuberculosis activity and could serve as important anti-tuberculosis drug leads.The functions of the pre-tailoring and the post-tailoring genes in the biosynthesis of ilamycins have been elucidated, but the functions of the

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Spatial Profiles of Intratumoral PD-1+ Helper T Cells Predict Prognosis in Head and Neck Squamous Cell Carcinoma

BackgroundFunctional interactions between immune cells and neoplastic cells in the tumor immune microenvironment have been actively pursued for both biomarker discovery for patient stratification, as well as therapeutic anti-cancer targets to improve clinical outcomes.Although accumulating evidence indicates that intratumoral infiltration of immune

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Should Rehabilitation Specialists Use External Focus Instructions When Motor Learning Is Fostered? A Systematic Review

According to the Constrained Action Hypothesis, motor learning is believed to be more efficient Wraps when an external focus (EF) of motor control is given to the performer instead of an internal focus (IF) of motor control.This systematic review investigated whether findings of studies focusing on the Constrained Action Hypothesis may be transferr

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